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Deutsche Zeitschrift für Onkologie 2011; 43(3): 106-111
DOI: 10.1055/s-0030-1257669
Forschung
© Karl F. Haug Verlag MVS Medizinverlage Stuttgart GmbH & Co. KG

Vitamin D und Krebs

Wolfgang Bayer
Further Information

Publication History

Publication Date:
21 October 2011 (online)

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Zusammenfassung

Zirka 60 % der deutschen Bevölkerung weisen einen Vitamin-D-Mangel auf, bestimmt über die Serumkonzentrationen von 25-Hydroxy-Vitamin D3. Vitamin D hat antikarzinogene Wirkungen wie Apoptose-Induktion oder Inhibierung der Angiogenese. Sonnenlichtexposition verbessert den Vitamin-D-Status und vermindert das Krebsrisiko für die meisten Tumor-Lokalisationen. Die überwiegende Zahl der Studien zeigt, dass niedrige Vitamin-D-Aufnahme oder niedrige Serumkonzentrationen von 25-Hydroxy-Vitamin D3 mit erhöhter Tumorinzidenz und -mortalität assoziiert sind. Bei Tumorpatienten sind höhere Serumkonzentrationen von 25-Hydroxy-Vitamin D3 mit niedriger Gesamt- und krebsspezifischer Mortalität korreliert.

Summary

About 60 % of the German population has an insufficient vitamin D status, determined by serum concentrations of 25-hydroxy-vitamin D3. Vitamin D exerts anticarcinogenic effects, including inhibition of angiogenesis and induction of apoptosis. Sunlight exposure, which improves the vitamin D status, lowers the total risk of cancer. Low vitamin D intake or low serum concentrations of 25-hydroxy-vitamin D3 are associated with increased cancer incidence and mortality in most but not all prospective studies or randomized controlled trials. In cancer patients higher concentrations of 25-hydroxy-vitamin D3 are interrelated with an improvement in overall survival.

Schlüsselwörter

Vitamin-D-Mangel - antikarzinogene Wirkungen - Tumorinzidenz und -mortalität - Überlebensrate bei Tumorpatienten -

Keywords

Vitamin D insufficiency - anticarcinogenic effects - cancer incidence - cancer mortality - survival in cancer patients
 

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