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Synthesis 2010(19): 3379-3383
DOI: 10.1055/s-0030-1257865
DOI: 10.1055/s-0030-1257865
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of α-Aminocyclopropylphosphonic Acids
Further Information
Publication History
Received
18 May 2010
Publication Date:
22 July 2010 (online)
Abstract
A convenient, general approach to α-aminocyclopropylphosphonic acids via reduction and hydrolysis of α-nitrocyclopropylphosphonates is described. A number of the title compounds were synthesized in excellent yields.
Key words
aminophosphonic acids - bioisosteres - cyclopropanes - reduction - hydrolysis