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Synthesis 2010(17): 2949-2956
DOI: 10.1055/s-0030-1258137
DOI: 10.1055/s-0030-1258137
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
gem-Dibromomethylarenes as Aldehyde Surrogates in the Pictet-Spengler Synthesis of Tetrahydroisoquinolines and Isoindoloisoquinolones
Further Information
Received
19 April 2010
Publication Date:
30 June 2010 (online)
Publication History
Publication Date:
30 June 2010 (online)

Abstract
A new variant of the Pictet-Spengler reaction has been developed using gem-dibromomethylarenes as aldehyde surrogates to afford a variety of tetrahydroisoquinoline and isoindoloisoquinolone ring systems in good yields. These systems comprise important motifs in naturally occurring bioactive substances.
Key words
Pictet-Spengler reaction - gem-dibromomethylarenes - tetrahydroisoquinolines - isoindoloisoquinolinones - microwave irradiation
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