Scaled-Up Transition-Metal-Catalyzed
Cross-Coupling Reactions of Thioether-Substituted N-Heterocycles
with Organozinc Reagents

Albrecht Metzger; Laurin Melzig; Paul Knochel

doi:10.1055/s-0030-1258145

PSP

Scaled-Up Transition-Metal-Catalyzed Cross-Coupling Reactions of Thioether-Substituted N-Heterocycles with Organozinc Reagents

Albrecht Metzger, Laurin Melzig, Paul Knochel*
Ludwig-Maximilians-Universität München, Department Chemie und Biochemie, Butenandtstr. 5-13, Haus F, 81377 München, Germany
Fax: +49(89)218077680; e-Mail: Paul.Knochel@cup.uni-muenchen.de;

Abstract

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Abstract

A variety of functionalized methylthio-substituted N-heterocycles (pyridines, pyrimidines, pyrazines, pyridazines, triazines, quinazolines, benzothiazoles) undergo smooth palladium- or nickel-catalyzed cross-couplings with highly functionalized organozinc reagents at ambient temperature. No expensive copper(I) salts are required and the coupling reactions proceed readily in the range of up to 20 mmol scale.

Key words

zinc organometallics - cross-coupling - thioether - palladium - nickel

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Referenzen

References

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