An effective one-pot, regioselective double Suzuki coupling of
2,4-dichloropyrimidine has been developed, which enables the quick
and efficient synthesis of diarylated pyrimidines. The choice of
solvent proved critical to the success of this reaction sequence,
with alcoholic solvent mixtures affording much greater reactivity
and requiring correspondingly lower temperatures than the use of
polar aprotic solvents.
pyrimidines - Suzuki coupling - regioselectivity - palladium-catalyzed - one-pot reaction
