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Synthesis 2010(18): 3070-3082
DOI: 10.1055/s-0030-1258157
DOI: 10.1055/s-0030-1258157
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Glycocluster Synthesis by Native Chemical Ligation
Weitere Informationen
Received
21 April 2010
Publikationsdatum:
07. Juli 2010 (online)
Publikationsverlauf
Publikationsdatum:
07. Juli 2010 (online)
Abstract
Serine- and mannoside-derived thioesters and a mannosidic cysteine derivative were prepared to test native chemical ligation (NCL) for protecting-group-free synthesis of small glycopeptide clusters, which are valuable tools in the glycosciences. The glycopeptides and glycopeptide clusters, respectively, which were obtained via NCL, bear the potential for dimerization and other derivatization of the thiol functionality.
Key words
carbohydrates - glycopeptides - glycoclusters - native chemical ligation - protecting-group-free synthesis
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- Supporting Information
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