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Synthesis 2010(21): 3602-3608
DOI: 10.1055/s-0030-1258234
DOI: 10.1055/s-0030-1258234
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Efficient Copper-Catalyzed S-Arylation of Thiols with Aryl Bromides and Chlorides
Weitere Informationen
Received
8 June 2010
Publikationsdatum:
30. August 2010 (online)
Publikationsverlauf
Publikationsdatum:
30. August 2010 (online)
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Abstract
An efficient copper-catalyzed system for C-S cross-coupling of aromatic thiols with aryl bromides and chlorides has been developed using 1,2,3,4-tetrahydroquinoline-8-ol as a ligand. It is noteworthy that this method is proved to be especially effective for aryl bromides with electron-donating groups. By this protocol, a variety of thioethers as well as symmetrical and unsymmetrical bis-thioethers are obtained in excellent yields with an exceptional level of functional group tolerance and high chemoselectivity.
Key words
copper catalyst - aryl bromides - aryl chlorides - cross-coupling - organic sulfides
- Supporting Information for this article is available online:
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