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Synthesis 2010(21): 3623-3626  
DOI: 10.1055/s-0030-1258240
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Novel and Efficient Method for the Synthesis of 1H-Indol-3-yl Acetates

Kexin Liu, Ping Wen, Jin Liu, Guosheng Huang*
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
Fax: +86(931)8912582; e-Mail: hgs2368@163.com;
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Publication History

Received 30 June 2010
Publication Date:
01 September 2010 (online)

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Abstract

A catalyst-free method for the synthesis of 1H-indol-3-yl acetates from 1H-indoles is described. The reaction takes place in the presence of (diacetoxyiodo)benzene (DIB) and potassium hydroxide as the base under mild conditions (MeCN, 35 ˚C, 1.5 h). This represents a simple and efficient new method for 1H-indol-3-yl acetate synthesis.

Key words

indoles - (diacetoxyiodo)benzene (DIB) - 1H-indol-3-yl acetates - oxidation

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