Abstract
Benzopyran-annulated thiopyrano[2,3-b]thiochromen-5(4H)-ones have been synthesized by the
domino Knoevenagel-hetero-Diels-Alder (DKHDA)
reaction of 4-hydroxydithiocoumarin with O-allylated salicylaldehyde
and O-propargylated salicylaldehyde in aqueous medium.
The reaction requires only a single step operation and is highly
regio- and stereoselective providing potentially bioactive polycyclic
heterocycles in high yields.
Key words
aqueous medium - domino Knoevenagel-hetero-Diels-Alder
reaction - stereoselective - regioselective - 4-hydroxydithiocoumarin
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