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Synthesis 2010(21): 3700-3704
DOI: 10.1055/s-0030-1258269
DOI: 10.1055/s-0030-1258269
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
A New and Improved Synthesis of the Precursor of the Hypoxia Marker [¹8F]-FMISO
Weitere Informationen
Received
23 June 2010
Publikationsdatum:
28. September 2010 (online)
Publikationsverlauf
Publikationsdatum:
28. September 2010 (online)
![](https://www.thieme-connect.de/media/synthesis/201021/lookinside/thumbnails/10.1055-s-0030-1258269-1.jpg)
Abstract
A new synthetic approach to the precursor of the hypoxia marker [¹8F]-FMISO has been developed. Three different tosylation methods were studied for the preparation of the key intermediate. The overall yield is markedly higher than the yields reported for previous syntheses. The precursor was used to prepare [¹8F]-FMISO and the results were comparable to those obtained when a commercial precursor was used.
Key words
[¹8F]-FMISO - hypoxia - radiopharmaceutical - regioselective tosylation
- Supporting Information for this article is available online:
- Supporting Information
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