Efficient Synthesis of Naturally
Occurring Skeleton 5-7-6 Tricyclic Pyrrolo[2,1-c][1,4]benzodiazepin-5-one
and Its Derivatives via Cationic π-Cyclization

Sudhir K. Sharma; Anil K. Mandadapu; K. Kumaresan; Ashish Arora; Harsh M. Gauniyal; Bijoy Kundu

doi:10.1055/s-0030-1258277

PAPER

Efficient Synthesis of Naturally Occurring Skeleton 5-7-6 Tricyclic Pyrrolo[2,1-c][1,4]benzodiazepin-5-one and Its Derivatives via Cationic π-Cyclization [¹]

Sudhir K. Sharma^a, Anil K. Mandadapu^a, K. Kumaresan^a, Ashish Arora^b, Harsh M. Gauniyal^c, Bijoy Kundu*^a
^a Division of Medicinal and Process Chemistry, Central Drug Research Institute, CSIR, Lucknow, 226001, India
Fax: +91(522)2623405; e-Mail: bijoy_kundu@yahoo.com; e-Mail: b_kundu@cdri.res.in;
^b Division of Molecular & Structural Biology, Central Drug Research Institute, CSIR, Lucknow, 226001, India
^c Sophisticated Analytical Instrument Facility, Central Drug Research Institute, CSIR, Lucknow, 226001, India

Abstract

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Abstract

An efficient method for the synthesis of a library based on the naturally occurring 5-7-6 tricyclic 5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one skeleton and its derivatives via cationic π-(7-endo) cyclization is described.

Key words

pyrrole - antibiotics - π-cyclization - oxidation - reduction

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