Conjugate Addition - SNAr
Domino Reaction for the Synthesis of Benzo- or Pyridyl-Fused Lactams
and Sultams

Niels Grøn Nørager; Karsten Juhl

doi:10.1055/s-0030-1258302

PAPER

Conjugate Addition - S_NAr Domino Reaction for the Synthesis of Benzo- or Pyridyl-Fused Lactams and Sultams

Niels Grøn Nørager^a,b, Karsten Juhl*^a
^a Medicinal Chemistry Research Denmark, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark
Fax: +4536438237; e-Mail: kaju@lundbeck.com;
^b Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark

Abstract

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Abstract

A versatile domino reaction that can be used for the synthesis of bicyclic benzo- or pyridyl-fused lactam and sultam derivatives is presented, enabling rapid synthesis of a variety of complex structures.

Key words

bicyclic compounds - domino reactions - heterocycles - Michael addition - nucleophilic aromatic substitution

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Referenzen

References

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Supporting Information

Conjugate Addition - SNAr Domino Reaction for the Synthesis of Benzo- or Pyridyl-Fused Lactams and Sultams

Conjugate Addition - S_NAr Domino Reaction for the Synthesis of Benzo- or Pyridyl-Fused Lactams and Sultams