α-Functionalization
of Carbonyl Compounds Using Hypervalent Iodine Reagents

Eleanor A. Merritt; Berit Olofsson

doi:10.1055/s-0030-1258328

REVIEW

α-Functionalization of Carbonyl Compounds Using Hypervalent Iodine Reagents

Eleanor A. Merritt, Berit Olofsson*
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden
Fax: +46(8)154908; e-Mail: berit@organ.su.se;

Abstract

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Abstract

α-Functionalized carbonyl compounds are versatile intermediates in organic synthesis. A broad range of both carbon and heteroatom substituents can be introduced into the α-position of carbonyl compounds using hypervalent iodine reagents. Herein we summarize the use of these environmentally benign reagents with particular emphasis on catalytic and asymmetric methodology developed over the past decade.

1 Introduction

2 Oxygenation

3 Halogenation

4 Trifluoromethylation

5 Arylation

6 Alkynylation and Alkenylation

7 Homocoupling

8 Functionalization of α,β-Unsaturated Carbonyl Compounds

9 Miscellaneous

10 Summary

Key words

catalysis - asymmetric synthesis - oxidation - hypervalent iodine - C-C bond formation

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Referenzen

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