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Synthesis 2011(2): 235-242
DOI: 10.1055/s-0030-1258354
DOI: 10.1055/s-0030-1258354
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Toward the Supramolecular Cyclodextrin Dimers Using Nucleobase Pairs
Further Information
Received
1 September 2010
Publication Date:
10 December 2010 (online)
Publication History
Publication Date:
10 December 2010 (online)
Abstract
The synthesis of eleven new cyclodextrin derivatives having nucleobase moiety - thymin-1-yl, adenin-9-yl, and guanin-9-yl - is described. These two moieties are linked by different spacers, such as aminoethyl and 1,2,3-triazolyl group. Direct nucleophilic substitution and 1,3-dipolar cycloaddition were performed in good yields (13-73%) for some of the synthesized compounds.
Key words
click chemistry - nucleobase - cyclodextrin
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References
6-Azido-β-CD, 6-amino-β-CD, 6-azido permethylated and 6-amino permethylated β-CD derivatives were furnished by Biocydex.