Glycerine and CeCl₃˙7H₂O: An Efficient and Recyclable Reaction Medium for Ring Opening of Epoxides with Thioamides and Amines

Abstract

Oxiranes undergo rapid ring-opening reaction with a range of thioamides and amines to afford the corresponding β-amino alcohol derivatives. The reactions were carried out using glycerine and cerium(III) chloride as a recyclable reaction medium. All the reactions were carried out at room temperature and the products were obtained in excellent yields.

Key words

epoxides - amines - thioamides - amino alcohols - glycerine - cerium chloride.

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  Narsaiah, A. V.; Kumar, J. K. Synth. Commun. 2010, submitted for publication.