Hydrogen Peroxide or Peracetic Acid Mediated Self-Titrating α-Halogenation of 1,3-Dicarbonyl Compounds

Abstract

Efficient oxidative α-halogenation of 1,3-dicarbonyl compounds has been achieved by employing a system comprising of sub-stoichiometric amounts of TiX₄ (X = Cl, Br) in conjunction with environmentally benign hydrogen peroxide (H₂O₂) or peracetic acid (MeCO₃H) as the oxidants. The end point of the reaction is accompanied by a sharp colour change.

Key words

halogenation - peroxides - titanium - halides - electrophilic

References

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22

For full analytical data of all products from Tables  [²] and  [³] with the exception of the products in Table  [²] , entry 7 and Table  [³] , entry 3, see reference 13.