Concise Total Synthesis of
Vicenistatin

Hayato Fukuda; Shiina Nakamura; Tadashi Eguchi; Yoshiharu Iwabuchi; Naoki Kanoh

doi:10.1055/s-0030-1258574

LETTER

Concise Total Synthesis of Vicenistatin

Hayato Fukuda^a, Shiina Nakamura^a, Tadashi Eguchi^b, Yoshiharu Iwabuchi^a, Naoki Kanoh*^a
^a Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan
Fax: +81(22)7956847; e-Mail: kanoh@mail.pharm.tohoku.ac.jp;
^b Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8551, Japan

Abstract

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Abstract

A highly convergent total synthesis of macrocyclic lactam glycoside vicenistatin is described. Key features of the synthesis include rapid assembly of the macrolactam part and macrocyclic ring closure via intramolecular Stille coupling.

Key words

vicenistatin - macrolactam - vicenisamine - total synthesis

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References and Notes

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