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Synlett 2010(17): 2553-2556  
DOI: 10.1055/s-0030-1258578
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Colorimetric Fluoride Sensor Based on a Bisthiourea Functionalized Molecular Clip

Liping Cao, Jiaoyang Ding, Jungang Wang, Yan Chen, Meng Gao, Weijian Xue, Anxin Wu*
Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, P. R. of China
e-Mail: chwuax@mail.ccnu.edu.cn;
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Publication History

Received 10 June 2010
Publication Date:
23 September 2010 (online)

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Abstract

A new class of bisthiourea-functionalized molecular clips were designed and synthesized for anion recognition. Clip 1 showed excellent affinity to the biologically relevant fluoride ion in a 1:1 ratio as shown by UV-vis, ¹H and ¹9F NMR studies. Moreover, the binding was accompanied with visually noticeable color changes, enabling the compound to act as a colorimetric fluoride sensor.

Key words

glycoluril - molecular clip - fluoride - sensor - thiourea

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