We report the use of benzylamine as the amine component in Hantzsch
ester mediated and chiral Brønsted acid catalyzed enantioselective
reductive aminations of ketones. The method is noteworthy because
the benzyl group is easily removable, and amine product purification
is achieved through Hantzsch ester oxidation product removal via
basic hydrolysis.
benzylamine - Hantzsch ester - reductive amination - organocatalysis - chiral amines - Brønsted
acids