Abstract
This account gives an overview of iridium-catalyzed reactions
developed by our group using mainly alcohols and diols as substrates.
In the presented reactions, the iridium catalyst serves as a hydrogen
acceptor from the alcohols giving iridium hydride, which is a key
transient species. Herein, we report hydrogenation, alkylation,
esterification, N-heterocyclization, and coupling reactions using
alcohols and diols as reagents.
1 Introduction
2 Hydrogenation of α,β-Unsaturated Carbonyl
Compounds and Alkenes
3 Synthesis of Vinyl and Allyl Ethers
4 Synthesis of γ,δ-Unsaturated Carbonyl Compounds
5 α-Alkylation Using Alcohols and Diols as Alkylating Agents
5.1 α-Alkylation of Methyl Ketones
5.2 α-Alkylation of Arylacetonitriles
5.3 α-Alkylation of Active Methylene Compounds
5.4 α-Alkylation of Acetates
6 β-Alkylation (Guerbet Reaction)
7 Oxidative Esterification
8 N-Heterocyclization
8.1 Synthesis of Quinolines from Amino Alcohols and Ketones
8.2 Synthesis of Benzo[h ]quinolines
and Benzoindole Derivatives from Naphthylamines and Diols
9 Coupling Reaction of Alcohols with Alkynes
9.1 Synthesis of Homoallylic Alcohols
9.2 Synthesis of α,β-Unsaturated Ketones (Hydroacylation)
10 Concluding Remarks
Key words
iridium - alcohols - transfer hydrogenations - alkylations - coupling
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