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Synthesis 2011(6): 979-983  
DOI: 10.1055/s-0030-1259487
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

First and Efficient Synthesis of 14-Aminophenanthroindolizidine Alkaloids

Ziwen Wang, Lei Wang, Qingmin Wang*
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. of China
Fax: 0086-022-23499842; e-Mail: wangqm@nankai.edu.cn;
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Publication History

Received 29 November 2010
Publication Date:
24 February 2011 (online)

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Abstract

14-Aminophenanthroindolizidine alkaloids and their N-acyl derivatives were prepared by a concise and efficient route ­involving a Parham-type cyclization as the key step.

Key words

alkaloids - metalations - cyclizations - drugs

3

The 60-cell line NCI test data, along with in vivo data, can be accessed from the corresponding NSC numbers at the following Web site: http://dtp.nci.nih.gov/dtpstandard/dwindex/index.jsp