The synthesis of polysubstituted indoles is described by the
domino reaction of 2-haloanilines and 1,3-dicarbonyl compounds,
1,3-diketones, β-keto esters and β-keto amides,
using copper catalysis under ligand-free conditions. The protocol
provides a simple, general and atom economical process for the synthesis
of substituted indoles at moderate temperature.
Cu2O - indoles - cesium carbonate - 1,3-dicarbonyl compounds - 2-haloanilines
