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Synthesis 2011(12): 1984-1987
DOI: 10.1055/s-0030-1260052
DOI: 10.1055/s-0030-1260052
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Diastereoselective Synthesis of Bicyclo[2.2.2]octan-2-one Derivatives through an Unexpected Organocatalytic Tandem Michael-Michael Reaction
Further Information
Received
11 April 2011
Publication Date:
17 May 2011 (online)
Publication History
Publication Date:
17 May 2011 (online)
![](https://www.thieme-connect.de/media/synthesis/201112/lookinside/thumbnails/10.1055-s-0030-1260052-1.jpg)
Abstract
An organocatalytic tandem Michael-Michael reaction is developed for the simple preparation of stereo complex, polycyclic compounds from simple reactants in satisfactory yields (up to 90%) and excellent diastereoselectivities (>30:1 dr).
Key words
organocatalysis - Michael reaction - tandem reaction - α,β-unsaturated ketones
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References
The crystallographic data for structure 3h in this paper have been deposited at the Cambridge Crystallographic Data Centre, Cambridge, CB2 1EZ, United Kingdom (CCDC 804550).