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Synthesis 2011(14): 2237-2246
DOI: 10.1055/s-0030-1260062
DOI: 10.1055/s-0030-1260062
SPECIALTOPIC
© Georg Thieme Verlag
Stuttgart ˙ New York
New Heterocyclic Inputs for the Povarov Multicomponent Reaction
Further Information
Received
28 March 2011
Publication Date:
09 June 2011 (online)
Publication History
Publication Date:
09 June 2011 (online)
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Abstract
Oxa-, thia- and imidazolones are reactive inputs as electron-rich olefin components in Povarov reactions. On interaction with anilines and aldehydes, these substrates afford the corresponding multicomponent adducts in a regioselective manner. Intramolecular processes are also explored. Post-condensation oxidation provides convenient access to a variety of fused quinoline derivatives.
Key words
domino reaction - heterocycles - imines - multicomponent reaction - quinolines
- Supporting Information for this article is available online:
- Supporting Information
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