Intramolecular Friedel-Crafts
Alkylation of Chalcone Epoxides Using Indium(III) Chloride
as an Efficient Catalyst

Naseem Ahmed; B. Venkata Babu; Harendra Kumar

doi:10.1055/s-0030-1260091

PAPER

Intramolecular Friedel-Crafts Alkylation of Chalcone Epoxides Using Indium(III) Chloride as an Efficient Catalyst

Naseem Ahmed*, B. Venkata Babu, Harendra Kumar
Department of Chemistry, Indian Institute of Technology, Roorkee 247 667, Uttarakhand, India
Fax: +91(1332)285745; e-Mail: nasemfcy@iitr.ernet.in;

Abstract

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Abstract

Indium(III) chloride catalyzes the ring opening of chalcone epoxides followed by intramolecular Friedel-Crafts alkylation under mild conditions at room temperature to afford highly functionalized 3-aryl-2-hydroxy-2,3-dihydro-1H-inden-1-ones in excellent yields (81-95%).

Key words

indium(III) chloride - intramolecular Friedel-Crafts alkylation - chalcones epoxides - epoxide ring opening - 2,3-dihydro-1H-inden-1-ones

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