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Synthesis 2011(17): 2833-2837
DOI: 10.1055/s-0030-1260128
DOI: 10.1055/s-0030-1260128
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkDirect Arylation of Pyrrole Derivatives in Superbasic Media
Further Information
Received
29 April 2011
Publication Date:
20 July 2011 (online)
Publication History
Publication Date:
20 July 2011 (online)
Abstract
Direct arylation of N-alkyl- and N-arylpyrroles with aryl iodides can be performed in superbasic media, without external addition of a transition-metal catalyst. Lithium hydroxide in dimethyl sulfoxide promotes this reaction in a regioselective manner, leading to the expected 2-arylated products in good yield.
Key words
pyrrole - heterocycles - C-C coupling - C-H activation - aryl halides
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