An Efficient and Recyclable
Magnetic-Nanoparticle-Supported Palladium Catalyst for
the Suzuki Coupling Reactions of Organoboronic Acids with Alkynyl
Bromides

Xiuli Zhang; Pinhua Li; Yong Ji; Lei Zhang; Lei Wang

doi:10.1055/s-0030-1260138

PAPER

An Efficient and Recyclable Magnetic-Nanoparticle-Supported Palladium Catalyst for the Suzuki Coupling Reactions of Organoboronic Acids with Alkynyl Bromides

Xiuli Zhang^a,b, Pinhua Li^c, Yong Ji^a, Lei Zhang^c, Lei Wang*^b,c
^a Department of Chemistry, Anhui Agricultural University, Hefei, Anhui 230036, P. R. of China
^b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China
^c Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. of China
Fax: +86(561)3090518; e-Mail: leiwang@chnu.edu.cn;

Abstract

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Abstract

A highly active, air- and moisture-stable and easily recoverable magnetic-nanoparticle-supported palladium catalyst has been developed for the Suzuki cross-coupling reaction of organoboron derivatives with alkynyl bromides. In the presence of palladium catalyst (0.5 mol%), organoboron derivatives including aromatic and aliphatic boronic acids, potassium aryltrifluoroborates, and sodium tetraphenylborate reacted smoothly with 1-bromo-2-substituted acetylenes to generate the corresponding cross-coupling products in good to excellent yields in ethanol. In addition, it is possible to recover and reuse the supported palladium catalyst at least 16 times without significant loss of its catalytic activity.

Key words

palladium catalyst - Suzuki coupling reaction - organoboronic acids - alkynyl bromides - magnetic nanoparticles

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