A versatile one-pot method was developed for the preparation
of a range of functionalized thieno[3,2-d]pyrimidine
and thieno[2,3-d]pyrimidine
derivatives. This protocol significantly reduces the cost and time
for the synthesis of these compounds in comparison with previous
routes, while facilitating scale up to multigram quantities in good
yields (66-99%). The technique also permits the
synthesis of bis(thienopyrimidine) derivatives not readily available
by other methods.
heterocycles - domino reaction - Wittig reaction - bicyclic compounds - cyclization
