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Synthesis 2011(11): 1705-1710
DOI: 10.1055/s-0030-1260461
DOI: 10.1055/s-0030-1260461
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of (-)-Actinonin
Further Information
Publication History
Received
8 October 2010
Publication Date:
05 May 2011 (online)


Abstract
Synthesis of (-)-actinonin in 17% overall yield was accomplished in seven steps via the formation of an isoimide derivative as the key intermediate. The synthesis was carried out using commercially available dimethyl maleate without the use of a highly expensive reagent.
Key words
actinonin - PDF inhibitor - antibacterial agent - total synthesis - catalytic hydrogenation