Synthesis 2011(11): 1705-1710  
DOI: 10.1055/s-0030-1260461
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Actinonin

Shin-ichi Inouea, Hiromi Nishiokaa, Hitoshi Abeb, Takashi Harayamaa, Yasuo Takeuchi*a
a Faculty of Pharmaceutical Sciences, Okayama University, Kitaku-tsushima-naka 1-1-1, Okayama 700-8530, Japan
Fax: +81(86)2517964; e-Mail: take@pharm.okayama-u.ac.jp;
b Faculty of Engineering, Toyama University, Gofuku 3190, Toyama 930-8555, Japan
Further Information

Publication History

Received 8 October 2010
Publication Date:
05 May 2011 (online)

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Abstract

Synthesis of (-)-actinonin in 17% overall yield was accomplished in seven steps via the formation of an isoimide derivative as the key intermediate. The synthesis was carried out using commercially available dimethyl maleate without the use of a highly expensive reagent.