Selective Reduction of Nitroarenes
by a Hantzsch 1,4-Dihydropyridine: A Facile and Efficient
Approach to Substituted Quinolines

Rui-Guang Xing; Ya-Nan Li; Qiang Liu; Yi-Feng Han; Xia Wei; Jing Li; Bo Zhou

doi:10.1055/s-0030-1260609

PAPER

Selective Reduction of Nitroarenes by a Hantzsch 1,4-Dihydropyridine: A Facile and Efficient Approach to Substituted Quinolines

Rui-Guang Xing^a, Ya-Nan Li^a, Qiang Liu*^a,b, Yi-Feng Han^b, Xia Wei^a, Jing Li^a, Bo Zhou^a
^a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. of China
^b Engineering Research Center for Eco-Dyeing & Finishing of Textiles, Ministry of Education, Zhejiang Sci-Tech University, Hangzhou 310018, P. R. of China
Fax: +86(931)8625657; e-Mail: liuqiang@lzu.edu.cn;

Abstract

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Abstract

An efficient reductive cyclization of o-nitrocinnamoyl compounds was achieved by employing a Hantzsch 1,4-dihydropyridine ester as a biomimetic reducing agent in the presence of catalytic palladium on carbon. This approach was successfully applied to the synthesis of substituted quinolines.

Key words

quinolines - reductive cyclization - Hantzsch ester - biomimetic reducing agent

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