Convertible Fluorous Linker
Assisted Synthesis of Tetrasubstituted Furans

Asha Kadam; Stephanie B. Buckley; Trinh Dinh; Ryan Fitzgerald; Wei Zhang

doi:10.1055/s-0030-1260767

LETTER

Convertible Fluorous Linker Assisted Synthesis of Tetrasubstituted Furans

Asha Kadam, Stephanie B. Buckley, Trinh Dinh, Ryan Fitzgerald, Wei Zhang*
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd., Boston, Massachusetts 02125, USA
Fax: +1(617)2876030; e-Mail: wei2.zhang@umb.edu;

Abstract

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Abstract

Tetrasubstituted furans are prepared by a three-step synthesis including condensation of a fluorous benzaldehyde with an acetophenone followed by Michael-type [3+2] cycloaddition with an 1,3-diketone and Pd-catalyzed coupling reaction for fluorous linker cleavage. The reactions are performed under microwave irradiation and the intermediate purifications are facilitated by fluorous solid-phase extraction (F-SPE).

Key words

fluorous linker - solid-phase extraction - tetrasubstituted furan - microwave reaction - multicomponent reaction - Suzuki coupling

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References

References and Notes

Selected reviews:

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Recent examples:

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See also ref. 11.

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General Procedure for the Synthesis of 5a: To a mixture of compound 3a (46 mg, 0.06 mmol) and β-keto ester 4b
(42 µL, 45 mg, 0.4 mmol) in AcOH (0.2 mL) were added Mn(OAc)₃ (128 mg, 0.48 mmol) and Cu(OAc)₂ (30 mg, 0.16 mmol). The mixture in a sealed tube was heated under microwave (Biotage Initiator 8) at 165 ˚C for 25 min. The reaction mixture was purified by F-SPE eluted with MeOH-H₂O (80:20, 15 mL) and then with MeOH (20 mL). The MeOH fraction was concentrated to give 5a (44 mg) in
84% yield. An analytical sample was obtained by further purification by flash chromatography (EtOAc-hexane, 7:3). ^¹H NMR (300 MHz, CDCl₃): δ = 2.61 (s, 3 H), 3.48 (s, 3 H), 3.76 (s, 3 H), 3.80 (s, 3 H), 6.80-6.86 (m, 3 H), 7.35-7.42 (m, 2 H), 7.80 (d, J = 8.7 Hz, 2 H). ^¹³C NMR (75 MHz, CDCl₃): δ = 13.9, 51.6, 55.5, 56.4, 110.5, 113.4, 114.0, 115.5, 119.6, 122.7, 126.3, 130.6, 131.7, 139.0, 146.9, 151.5, 158.7, 163.3, 164.1, 191.2. LC-MS (APCI+): m/z = 879 [M + 1]⁺. HRMS (ES+): m/z [M + H]⁺ calcd for C₃₀H₂₀O₉F₁₇S: 879.0550; found: 879.0557.
General Procedure for the Synthesis of 7c: A mixture of 5a (75 mg, 0.085 mmol) and p-tolylboronic acid (17 mg, 0.125 mmol), Pd(dppf)Cl₂ (8.5 mg, 8 mol%) and Cs₂CO₃ (55 mg, 0.16 mmol) in co-solvent of acetone-H₂O-HFE7200 (C₄F₉OEt) (4:1:4) in a sealed tube was heated under microwave (Biotage Initiator 8) at 130 ˚C for 30 min. The reaction mixture was purified by flash chromatography (EtOAc-hexanes, 7:3) to give 7c (23 mg) in 59% yield. ^¹H NMR (300 MHz, CDCl₃): δ = 2.30 (s, 3 H), 2.60 (s, 3 H), 3.50 (s, 3 H), 3.68 (s, 3 H), 3.77 (s, 3 H), 6.75-6.84 (m, 3 H), 7.12 (d, J = 8.1 Hz, 2 H), 7.22 (m, 2 H), 7.35 (d, J = 2.4 Hz, 1 H), 7.44 (d, J = 4.2 Hz, 1 H), 7.80 (d, J = 9.4 Hz, 2 H). ^¹³C NMR (75 MHz, CDCl₃): δ = 13.9, 21.3, 51.5, 55.6, 56.7, 111.3, 114.0, 115.3, 122.0, 125.9, 128.4, 128.8, 129.0, 129.4, 130.9, 131.1, 131.8, 134.9, 137.0, 149.2, 156.8, 158.1, 163.6, 163.9, 191.7. LC-MS (APCI+): m/z = 471
[M + 1]⁺. HRMS (ES+): m/z [M + H]⁺ calcd for C₂₉H₂₇O₆: 471.1806; found: 471.1808.
General Procedure for the Synthesis of 9a: Compound 5a (60 mg, 0.068 mmol), Pd₂(dba)₃ (0.32 mg, 5 mol%), JohnPhos (0.20 mg, 10 mol%) and DBU (252 µL, 0.17 mmol) were added to the flask under a nitrogen atmosphere. Then p-trifluoromethylaniline (81 µL, 0.08 mmol) in toluene (0.2 mL) was added. The mixture in a sealed tube was heated under microwave (Biotage Initiator 8) at 130 ˚C for 30 min. The reaction mixture was purified by flash chromatography (EtOAc-hexanes, 7:3) to give 9a (25 mg) in 69% yield. ^¹H NMR (300 MHz, CDCl₃): δ = 2.60 (s, 3 H), 3.47 (s, 3 H), 3.77 (s, 3 H), 3.78 (s, 3 H), 6.18 (s, 1 H), 6.74-6.87 (m, 5 H), 7.09-7.18 (m, 3 H), 7.28-7.34 (m, 1 H), 7.80 (d, J = 9.0 Hz, 2 H).^¹³C NMR (75 MHz, CDCl₃): δ = 14.0, 51.5, 55.5, 55.8, 110.9, 113.2, 114.0, 115.2, 116.3, 116.9, 117.3, 119.0, 119.4, 122.0, 126.7, 126.7, 130.9, 131.2, 131.8, 145.4, 149.1, 158.2, 163.5, 164.0, 191.7. LC-MS (APCI+): m/z = 540 [M + 1]⁺. HRMS (ES+): m/z [M + H]⁺ calcd for C₂₉H₂₅F₃NO₆: 540.1632; found: 540.1634.

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