Abstract
A concise and versatile syntheses of 11-16-membered macrolides
and 13-15-membered macrolactams have been achieved using
a Tsuji-Trost type reaction. This approach is composed
of intramolecular cyclization employing ethyl carbonate with carboxylic
acids and catalytic amount of Pd(PPh3 )4 to
form carbon-heteroatom covalent bonds with no use of stoichiometric
reagents.
Key words
macrolactones - macrolactams - palladium-catalyzed reaction - carbon-heteroatom bond formation
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[4
Scheme 4
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(Scheme
[5
Scheme 5
