Asymmetric Organocatalyzed Direct Aldol Additions of Enolizable Aldehydes

Abstract

The enantioselective direct cross-aldol addition between enolizable aldehydes is of great importance because this transformation provides access to configurationally defined β-hydroxyaldehydes. These products in turn are valuable building blocks in total syntheses of natural polyketide structures. This account gives an overview of advances made in this field of organocatalysis.

1 Introduction

2 Direct Aldol Additions of Enolizable Aldehydes Catalyzed by Proline, Proline Derivatives, and Imidazolidinone

2.1 Direct Aldol Additions Catalyzed by Proline and Proline Derivatives

2.2 Direct Aldol Additions Catalyzed by Imidazolidinone

3 Direct Aldol Additions of Enolizable Aldehydes Catalyzed by Histidine

4 Conclusion

aldol reactions - enolizable aldehydes - asymmetric ­catalysis - organocatalysis - stereoselectivity

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Scheffler, U.; Mahrwald R. in preparation.