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DOI: 10.1055/s-0030-1260813
Asymmetric Organocatalyzed Direct Aldol Additions of Enolizable Aldehydes
Publication History
Publication Date:
05 July 2011 (online)
Abstract
The enantioselective direct cross-aldol addition between enolizable aldehydes is of great importance because this transformation provides access to configurationally defined β-hydroxyaldehydes. These products in turn are valuable building blocks in total syntheses of natural polyketide structures. This account gives an overview of advances made in this field of organocatalysis.
1 Introduction
2 Direct Aldol Additions of Enolizable Aldehydes Catalyzed by Proline, Proline Derivatives, and Imidazolidinone
2.1 Direct Aldol Additions Catalyzed by Proline and Proline Derivatives
2.2 Direct Aldol Additions Catalyzed by Imidazolidinone
3 Direct Aldol Additions of Enolizable Aldehydes Catalyzed by Histidine
4 Conclusion
Key words
aldol reactions - enolizable aldehydes - asymmetric catalysis - organocatalysis - stereoselectivity
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For primary amine catalysis, see: ref. 2a
26Scheffler, U.; Mahrwald R. in preparation.