Synthesis of Optically Pure
1-Amino-3-aryl Indanes Exemplified by (+)-Indatraline

Niels Grøn Nørager; Linda Luise Reeh Lorentz-Petersen; Lars Ole Lyngsø; Jan Kehler; Karsten Juhl

doi:10.1055/s-0030-1260823

LETTER

Synthesis of Optically Pure 1-Amino-3-aryl Indanes Exemplified by
(+)-Indatraline

Niels Grøn Nørager^a,b, Linda Luise Reeh Lorentz-Petersen^a,c, Lars Ole Lyngsø^d, Jan Kehler^a, Karsten Juhl*^a
^a Discovery Chemistry and DMPK, H., Lundbeck A/S, Otilliavej 9, 2500 Valby, Denmark
Fax: +45(364)38237; e-Mail: kaju@lundbeck.com;
^b Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark
^c Department of Chemistry, Technical University of Denmark, Bldg. 201, Kemitorvet, 2800 Kgs. Lyngby, Denmark
^d Process Research, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark

Abstract

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Abstract

A versatile procedure for the synthesis of optically pure 1-amino-3-aryl indanes is presented, exemplified by the synthesis of the triple uptake inhibitor (+)-indatraline (1).

Key words

indane - indatraline - enzymatic resolution - conjugate addition - rhodium

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Referenzen

References

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Zusatzmaterial

Supporting Information

Synthesis of Optically Pure 1-Amino-3-aryl Indanes Exemplified by (+)-Indatraline

Synthesis of Optically Pure 1-Amino-3-aryl Indanes Exemplified by
(+)-Indatraline