Abstract
A simple and efficient copper-catalyzed method for synthesis
of fused pyridoquinazolones has been developed without addition
of any ligand or additive, and it can tolerate various functional
groups.
Key words
N-heterocycle - pyridoquinazolone - copper - synthetic method
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17
General Procedure
for the Synthesis of Compounds 2a-n
A two-necked,
round-bottom flask was charged with a magnetic stirrer, evacuated,
and back-filled with nitrogen. Substituted 2-halo-N -(pyridin-2-yl)arylamide
(1 ) (0.5 mmol), Cs2 CO3 (1
mmol, 326 mg), and toluene (2 mL) were added to the flask. After
a 10 min stirring at r.t. under nitrogen atmosphere, CuI (0.025
mmol, 5 mg) was added to the flask. The mixture was stirred at 110 ˚C
for 24 or 36 h (see Table
[²
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