Abstract
Mannich-type reactions with nitrones, oximes, and hydrazones
provide efficient approaches to β-amino carbonyl derivatives
with nitrogen functionality existing in an intermediate oxidation
state, as in the cases of hydroxylamine and hydrazine derivatives.
By employing chiral substrates and catalysts enantiomerically pure
substances can be prepared by using these processes.
1 Introduction
2 Mannich-Type Reactions with Nitrones
2.1 Metal Enolates
2.2 Silyl Ketene Acetals
3 Mannich-Type Reactions with Oximes
4 Mannich-Type Reactions with Hydrazones
5 Concluding Remarks
Key words
Mannich bases - nitrones - hydrazones - oximes - nucleophilic addition - hydroxylamines - hydrazines
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