Clinical Value of the 11- to 13+6-Week Sonogram for Detection of Congenital Malformations: A Review

Antoni Borrell; Julian N Robinson; Joaquin Santolaya-Forgas

doi:10.1055/s-0030-1263302

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2011; 28(2): 117-124
DOI: 10.1055/s-0030-1263302

Clinical Value of the 11- to 13⁺⁶-Week Sonogram for Detection of Congenital Malformations: A Review

Antoni Borrell¹ , Julian N. Robinson² , Joaquin Santolaya-Forgas³

¹Prenatal Diagnosis Unit, Institute of Gynecology, Obstetrics and Neonatology, Hospital Clinic, Barcelona, Catalonia, Spain
²Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts
³Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey

Abstract

ABSTRACT

We sought to determine the clinical value of the 11- to 13⁺⁶-week ultrasound evaluation for diagnosis of congenital abnormalities. A literature search was conducted for publications concerning the use of the 11- to 13⁺⁶-week ultrasound evaluation for prenatal diagnosis of congenital abnormalities. Series with more than 1000 cases published in the English language were selected. The reported data were integrated and a pooled analysis was performed to provide meaningful clinical interpretations. Our analysis of data from 36,237 pregnancies generated by eight centers suggests that the overall detection rate of major congenital anomalies during the 11- to 13⁺⁶-week ultrasound evaluation is 29% (95% confidence interval 25 to 33). Prenatal diagnosis at these stages of development could improve if evaluations are implemented in accordance to very well delineated protocols.

KEYWORDS

Prenatal ultrasonography - fetal malformations - fetal anatomy - prenatal diagnosis - first trimester ultrasound

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Referenzen

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Antoni BorrellM.D.

Prenatal Diagnosis Unit. Institute of Gynecology, Obstetrics and Neonatology, Hospital Clinic, Maternitat Campus

Sabino Arana 1, 08028 Barcelona, Catalonia, Spain

eMail: aborrell@clinic.ub.es