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DOI: 10.1055/s-0030-1264439
Bioactivity profile of compounds isolated from Hymenocardia acida Tul. leaves
In the course of phytochemical investigations to determine the different constituents of H. acida we isolated di (2-ethylhexyl) phthalate (DEPH) and homoorientin. These compounds were subjected to several assays for bioactivity profiling viz: antioxidant, in vitro anti-inflammatory, cytotoxicity and antimicrobial studies. Homoorientin inhibited hydroxyl radicals generation in horse radish assay but failed to inhibit superoxide in xanthine-xanthine assay, while DEPH did not show any antioxidant property. DEPH and Homoorientin showed moderate inhibition of 3α-hydroxysteroid dehydrogenase with an IC50 of 10 and 16µg/ml respectively. The compounds did not show good activity against the micro-organisms tested. The results of this study lend credence to the ethnomedicinal use of H. acida as an anti-inflammatory agent (1) and expand knowledge on the biological activity of its secondary metabolites.
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