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Semin Thromb Hemost 2010; 36(8): 881-887
DOI: 10.1055/s-0030-1267042
© Thieme Medical Publishers

Platelet- and Megakaryocyte-Derived Microparticles

Robert Flaumenhaft1 , Albert T.A. Mairuhu1 , Joseph E. Italiano2 , 3
  • 1Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
  • 2Division of Translational Medicine, Brigham and Women's Hospital, Boston, Massachusetts
  • 3Vascular Biology Program, Department of Surgery, Children's Hospital Boston, Boston, Massachusetts
Further Information

Publication History

Publication Date:
03 November 2010 (online)

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ABSTRACT

Platelet microparticles are the most abundant cell-derived microparticle subtype in the circulation. Yet the mechanism by which platelet microparticles are formed is poorly defined. This review highlights the concept of the generation of microparticles from platelets and their precursor cells, megakaryocytes. Special emphasis is placed on the mechanisms of microparticle formation and novel functions for microparticles in normal physiology and disease states.

KEYWORDS

Microparticle - platelet - megakaryocyte - cytoskeleton

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Robert FlaumenhaftM.D. Ph.D. 

Center for Life Sciences, Room no. 939

Beth Israel Deaconess Medical Center, 3 Blackfan Circle, Boston, MA 02215

Email: rflaumen@bidmc.harvard.edu