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Semin Thromb Hemost 2010; 36(8): 907-916
DOI: 10.1055/s-0030-1267044
© Thieme Medical Publishers

Microparticles: Key Protagonists in Cardiovascular Disorders

Nicolas Amabile1 , 3 [*] , Pierre-Emmanuel Rautou1 [*] , Alain Tedgui1 , 2 , Chantal M. Boulanger1 , 2
  • 11 INSERM, U970, Paris Cardiovascular Research Center – PARCC, Paris, France
  • 2Université Paris Descartes, UMR-S970, Paris, France
  • 3Cardiology Department, Marie Lannelongue Center, Le Plessis Robinson, France
Further Information

Publication History

Publication Date:
10 November 2010 (online)

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ABSTRACT

Microparticles (MP) are shed membrane vesicles released by various cell types following apoptosis or activation. MP circulate in human plasma and also accumulate in atherosclerotic lesions. A growing body of evidence has highlighted their involvement in inflammation, angiogenesis, coagulation, and the regulation of vascular tone. MP may therefore contribute to the initiation and development of atherosclerosis and its complications. Plasma MP originate from platelets, leukocytes, erythrocytes, and endothelial cells, and their levels increase in patients with cardiovascular diseases; specific cardiovascular medications also affect plasma MP levels. Most recent data suggest a potential prognostic role of circulating MP for identification of subjects prone to develop cardiovascular complications.

KEYWORDS

Microparticles - endothelial dysfunction - inflammation - coagulation - angiogenesis

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1 Both authors contributed equally to the work.

Chantal M BoulangerPh.D. 

Paris – Cardiovascular Research Center at HEGP

1 INSERM - U970, 56, rue Leblanc, 75015 Paris, France

Email: chantal.boulanger@inserm.fr