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Exp Clin Endocrinol Diabetes 2011; 119(3): 186-189
DOI: 10.1055/s-0030-1267201
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Plasma Glucose After Stomach or Jejunum Glucose Infusion in Roux-En-Y Gastric Bypass Patients – a Possible Implication for Early Satiety Mechanism

L. Czupryniak1 , M. Pawłowski1 , D. Szymański2 , W. Olejniczak2 , M. Saryusz-Wolska1 , J. Loba1 , J. Strzelczyk2
  • 1Department of Internal Medicine and Diabetology, Barlicki University Hospital No 1, Medical University of Lodz, Lodz, Poland
  • 2Department of General and Transplant Surgery, Barlicki University Hospital No 1, Medical University of Lodz, Lodz, Poland
Further Information

Publication History

received 11.05.2010 first decision 15.08.2010

accepted 20.09.2010

Publication Date:
03 March 2011 (online)

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Abstract

Background: Morbidly obese patients undergoing gastric bypass surgery experience early satiety soon after the surgery; the mechanism of this effect is poorly understood. As blood glucose concentration plays a role in appetite regulation in humans, we hypothesized that after gastric bypass surgery glucose absorbed mainly in jejunum leads to a greater rise in plasma glucose that if it is ingested in stomach.

Material and Methods: 24 non-diabetes morbidly obese patients (15 women, 9 men, mean age [±SD] 35.6±11.9 years, body weight 140.7±33.1 kg, BMI 46.8±8.3 kg/m2) undergoing Roux-en-Y gastric bypass surgery were given 10 ml of 40% glucose solution to the stomach before its size reduction and to the jejunum after gastro-jejunal anastomosis was formed.

Results: After jejunal infusion blood glucose increased more rapidly and was ∼30% higher than after stomach infusion. Moreover, this increase was less pronounced in more obese patients.

Conclusion: In patients after Roux-en-Y gastric bypass surgery glucose absorbed in jejunum leads to greater rise in plasma glucose concentration than if it is ingested in stomach. This phenomenon may help explain satiety feeling occurring early in gastric bypass surgery patients.

Key words

morbid obesity - gastric bypass - food intake - appetite - insulin - glucose

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Correspondence

Dr. L. Czupryniak

Barlicki University Hospital No 1

Medical University of Lodz

Ul. Kopcinskiego 22

90–153 Lodz

Poland

Phone: +48/42/6776 663

Fax: +48/42/6786 480

Email: bigosik@poczta.onet.pl