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DOI: 10.1055/s-0030-1267202
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Obesity of TallyHO/JngJ Mouse Is Due to Increased Food Intake with Early Development of Leptin Resistance
Publikationsverlauf
received 04.05.2010
first decision 31.08.2010
accepted 20.09.2010
Publikationsdatum:
28. Oktober 2010 (online)

Abstract
TALLYHO/JngJ (TallyHo) mouse is a recently established animal model for type 2 diabetes mellitus (T2DM) with phenotypes of mild obesity and male-limited hyperglycemia. In this study, we investigated how obesity develops in TallyHo mice by measuring parameters of food intake and energy expenditure. At 4 weeks of age, TallyHo mice were heavier than control C57BL/6 mice with increased food intake but comparable energy expenditure parameters, such as body temperature, cold-induced thermogenesis, oxygen consumption rate (VO2) and spontaneous locomotor activity. Furthermore, pair-fed TallyHo mice, which were fed the same amount of food as C57BL/6 mice, showed similar patterns of body weight gain to C57BL/6 mice at all ages, implying that obesity in TallyHo mice may develop by increased food intake but not by decreased energy consumption. TallyHo mice appear to have hypothalamic leptin resistance at 4 weeks of age, as indicated by the increased expression of orexigenic neuropeptides in the hypothalamus and no alteration of food intake and neuropeptide expression upon intravenous leptin treatment. Leptin injection to TallyHo mice, however, increased the phosphorylation of STAT3 and Akt, an important signaling mediator of leptin, in a pattern similar to that in C57BL/6 mice. In conclusion, increased food intake is a crucial component in the development of obesity in TallyHo mice, in which central leptin resistance, possibly caused by uncoupling between activation of leptin signaling and neuropeptide expression, might be involved.
Key words
tallyho mice - leptin - food intake - energy expenditure - obesity
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Correspondence
H. G. Cheon,PhD
Department of Pharmacology and Pharmaceutical Sciences
Gachon University of Medicine and Science
Yeonsu-3 dong
Yeonsu-Gu
406-799 Incheon
Korea
Telefon: +82/32/820 4761
Fax: +82/32/820 4744
eMail: hgcheon@gachon.ac.kr