Resistance Exercise and Lipoproteins in Postmenopausal Women

Abstract

The specific aims of this study were to quantify the effects of 12 weeks of resistance training, as well as a single session of resistance exercise on lipids and lipoproteins in obese, postmenopausal women. 21 obese, postmenopausal women, not on hormone replacement therapy (age=65.9±0.5 yr; BMI=32.7±0.8 kg/m²), were randomly assigned to control (n=12) and exercise (n=9) groups matched for age and BMI. For 12 weeks, 3 days/week, the exercise group performed 10 whole body resistance exercises (3 sets at 8-RM). Fasting (10 h) blood samples were collected immediately prior to and 24 h after the first and last exercise and control session. Serum was assayed for concentrations of total cholesterol, triglycerides, LDL-C, HDL-C, HDL 2-C, HDL 3-C, non-HDL-C and TC:HDL and LDL:HDL ratios. The exercise group exhibited a significant (P<0.01) improvement in muscular strength, but no change in BMI, body mass or body composition post-training. Total cholesterol, LDL-C and non-HDL-C were significantly (P<0.05) lower in the exercise compared to the control group following the 12 weeks of resistance training. Whole body resistance training provides obese, postmenopausal women a non-pharmacological approach for the reduction of lipid and lipoprotein-cholesterol concentrations.

cholesterol - exercise - menopause - obesity

References

• 1 Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) . Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III).  JAMA. 2001;  285 2486-2497
• 2 Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, Kirby A, Sourjina T, Peto R, Collins R, Simes R. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.  Lancet. 2005;  366 1267-1278
• 3 Banz WJ, Maher MA, Thompson WG, Bassett DR, Moore W, Ashraf M, Keefer DJ, Zemel MB. Effects of resistance versus aerobic training on coronary artery disease risk factors.  Exp Biol Med. 2003;  228 434-440
• 4 Bemben DA, Bemben MG. Effects of resistance exercise and body mass index on lipoprotein-lipid patterns of postmenopausal women.  J Strength Cond Res. 2000;  14 80-85
• 5 Boyden TW, Pamenter RW, Going SB, Lohman TG, Hall MC, Houtkooper LB, Bunt JC, Ritenbaugh C, Aickin M. Resistance exercise training is associated with decreases in serum low-density lipoprotein cholesterol levels in premenopausal women.  Arch Intern Med. 1993;  153 97-100
• 6 Carroll MD, Lacher DA, Sorlie PD, Cleeman JI, Gordon DJ, Wolz M, Grundy SM, Johnson CL. Trends in serum lipids and lipoproteins of adults, 1960–2002.  JAMA. 2005;  294 1773-1781
• 7 Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, Roubenoff R, Tucker KL, Nelson ME. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes.  Diabetes Care. 2002;  25 2335-2341
• 8 Cho GJ, Lee JH, Park HT, Shin JH, Hong SC, Kim T, Hur JY, Lee KW, Park YK, Kim SH. Postmenopausal status according to years since menopause as an independent risk factor for the metabolic syndrome.  Menopause. 2008;  15 524-529
• 9 Colado JC, Triplett NT, Tella V, Saucedo P, Abellan J. Effects of aquatic resistance training on health and fitness in postmenopausal women.  Eur J Appl Physiol. 2009;  106 113-122
• 10 Cui Y, Blumenthal RS, Flaws JA, Whiteman MK, Langenberg P, Bachorik PS, Bush TL. Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality.  Arch Intern Med. 2001;  161 1413-1419
• 11 Dalleck LC, Allen BA, Hanson BA, Borresen EC, Erickson ME, De Lap SL. Dose-response relationship between moderate-intensity exercise duration and coronary heart disease risk factors in postmenopausal women.  J Womens Health. 2009;  18 105-113
• 12 Durstine JL, Grandjean PW, Cox CA, Thompson PD. Lipids, lipoproteins, and exercise.  J Cardiopulm Rehabil. 2002;  22 385-398
• 13 Elliott KJ, Sale C, Cable NT. Effects of resistance training and detraining on muscle strength and blood lipid profiles in postmenopausal women.  Br J Sports Med. 2002;  36 340-344
• 14 Fabbri G, Maggioni AP. Cardiovascular risk reduction: what do recent trials with rosuvastatin tell us?.  Adv Ther. 2009;  26 469-487
• 15 Fahlman MM, Boardley D, Lambert CP, Flynn MG. Effects of endurance training and resistance training on plasma lipoprotein profiles in elderly women.  J Gerontol A Biol Sci Med Sci. 2002;  57 B54-60
• 16 Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.  Clin Chem. 1972;  18 499-502
• 17 Frost PH, Havel RJ. Rationale for use of non-high-density lipoprotein cholesterol rather than low-density lipoprotein cholesterol as a tool for lipoprotein cholesterol screening and assessment of risk and therapy.  Am J Cardiol. 1998;  81 26B-31B
• 18 Gidez LI, Miller GJ, Burstein M, Slagle S, Eder HA. Separation and quantitation of subclasses of human plasma high density lipoproteins by a simple precipitation procedure.  J Lipid Res. 1982;  23 1206-1223
• 19 Grandjean PW, Crouse SF, Rohack JJ. Influence of cholesterol status on blood lipid and lipoprotein enzyme responses to aerobic exercise.  J Appl Physiol. 2000;  89 472-480
• 20 Harber MP, Crane JD, Douglass MD, Weindel KD, Trappe TA, Trappe SW, Fink WF. Resistance exercise reduces muscular substrates in women.  Int J Sports Med. 2008;  29 719-725
• 21 Harriss DJ, Atkinson G. International Journal of Sports Medicine - Ethical Standards in Sport and Exercise Science Research.  Int J Sports Med. 2009;  30 701-702
• 22 Hill S, Bermingham MA, Knight PK. Lipid metabolism in young men after acute resistance exercise at 2 different intensities.  J Sci Med Sport. 2005;  8 441-445
• 23 Hills AP, Shultz SP, Soares MJ, Byrne NM, Hunter GR, King NA, Misra A. Resistance training for obese, type 2 diabetic adults: a review of the evidence.  Obes Rev. 2009; 
• 24 Honkola A, Forsen T, Eriksson J. Resistance training improves the metabolic profile in individuals with type 2 diabetes.  Acta Diabetol. 1997;  34 245-248
• 25 Jackson AS, Pollock ML, Ward A. Generalized equations for predicting body density of women.  Med Sci Sports Exerc. 1980;  12 175-181
• 26 Kelley GA, Kelley KS. Impact of progressive resistance training on lipids and lipoproteins in adults: a meta-analysis of randomized controlled trials.  Prev Med. 2009;  48 9-19
• 27 Nash MS, Jacobs PL, Mendez AJ, Goldberg RB. Circuit resistance training improves the atherogenic lipid profiles of persons with chronic paraplegia.  J Spinal Cord Med. 2001;  24 2-9
• 28 Pischon T, Girman CJ, Sacks FM, Rifai N, Stampfer MJ, Rimm EB. Non-high-density lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men.  Circulation. 2005;  112 3375-3383
• 29 Ren J, Kelley RO. Cardiac health in women with metabolic syndrome: clinical aspects and pathophysiology.  Obesity. 2009;  17 1114-1123
• 30 Siri WE. Body composition from fluid spaces and density: analysis of methods.  Nutrition. 1993;  9 480-491
• 31 Sumino H, Ichikawa S, Yoshida A, Murakami M, Kanda T, Mizunuma H, Sakamaki T, Kurabayashi M. Effects of hormone replacement therapy on weight, abdominal fat distribution, and lipid levels in Japanese postmenopausal women.  Int J Obes Relat Metab Disord. 2003;  27 1044-1051
• 32 Tadmor OP, Kleinman Y, Goldstein R, Diamant YZ. The effect of desogestrel for hormone replacement therapy on the blood lipid profiles of postmenopausal women.  Int J Gynaecol Obstet. 1992;  39 105-110
• 33 Tanko LB, Bagger YZ, Qin G, Alexandersen P, Larsen PJ, Christiansen C. Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women.  Circulation. 2005;  111 1883-1890
• 34 Tsekouras YE, Magkos F, Prentzas KI, Basioukas KN, Matsama SG, Yanni AE, Kavouras SA, Sidossis LS. A single bout of whole-body resistance exercise augments basal VLDL-triacylglycerol removal from plasma in healthy untrained men.  Clin Sci (Lond). 2009;  116 147-156
• 35 Vincent KR, Braith RW, Bottiglieri T, Vincent HK, Lowenthal DT. Homocysteine and lipoprotein levels following resistance training in older adults.  Prev Cardiol. 2003;  6 197-203
• 36 Wallace MB, Moffatt RJ, Haymes EM, Green NR. Acute effects of resistance exercise on parameters of lipoprotein metabolism.  Med Sci Sports Exerc. 1991;  23 199-204
• 37 Warnick GR, Albers JJ. A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol.  J Lipid Res. 1978;  19 65-76
• 38 Wooten JS, Biggerstaff KD, Anderson C. Response of lipid, lipoprotein-cholesterol, and electrophoretic characteristics of lipoproteins following a single bout of aerobic exercise in women.  Eur J Appl Physiol. 2008;  104 19-27

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