ABSTRACT
We sought to determine the efficacy and safety of tranexamic acid (TA) in reducing
blood loss during elective cesarean section (CS). We performed a randomized, double-blind,
placebo-controlled study of 660 women who underwent elective CS. The patients were
randomly selected to receive an intravenous infusion of either TA (1 g/10 mL in 20
mL of 5% glucose; n = 330) or 30 mL 5% glucose prior to surgery. The primary outcome was the estimated
blood loss following CS. No demographic difference was observed between groups. The
mean estimated blood loss was significantly lower in women treated with TA compared
with women in the placebo group (499.9 ± 206.4 mL versus 600.7 ± 215.7 mL, respectively;
p < 0.001), and the proportion of women in the TA group who had an estimated blood
loss >1000 mL was significantly lower than in the placebo group (7 [2.1%] versus 19
[5.8%], respectively; relative risk [RR] 2.7; 95% confidence interval [CI] 1.1 to
6.3; p < 0.03). Furthermore, more women in the placebo group than in the TA group required
additional uterotonic agents (48 [14.5%] versus 28 [8.5%], respectively; RR 1.7; 95%
CI 1.1 to 2.6; p = 0.02). Maternal and neonatal outcomes did not differ significantly. TA significantly
reduced bleeding during CS, the percentage of patients with blood loss >1000 mL, and
the need for additional uterotonic agents. Furthermore, the incidence of thromboembolic
events did not increase. Our results suggest that TA can be used safely and effectively
to reduce CS bleeding.
KEYWORDS
Tranexamic acid - cesarean section - blood loss - randomized control trial
REFERENCES
maidenkemal@yahoo.com
