Low Vitamin D Levels in Northern American Adults with the Metabolic Syndrome

S. Devaraj; G. Jialal; T. Cook; D. Siegel; I. Jialal

doi:10.1055/s-0030-1268485

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2011; 43(1): 72-74
DOI: 10.1055/s-0030-1268485

Short Communication

Low Vitamin D Levels in Northern American Adults with the Metabolic Syndrome

S. Devaraj¹ , G. Jialal¹ , T. Cook¹ , D. Siegel¹ ^, ² , I. Jialal¹ ^, ²

¹Department of Pathology and Laboratory Medicine, University of California, Davis, Medical Center, Sacramento, CA, USA
²Veterans Affairs Medical Center, Mather, CA, USA

Abstract

Metabolic syndrome (MetS), is a constellation of cardiometabolic disease risk factors, that affects 1 in 3 US adults and predisposes to increased risks for both diabetes and cardiovascular disease. While epidemiological studies show low vitamin D [(25(OH)D] levels in MetS, there is sparse data on vitamin D status in MetS patients in North America. Thus, the aim of our study was to examine plasma vitamin D concentration among adults with MetS in Northern California (sunny climate), but without diabetes or cardiovascular disease. 25(OH)D levels were significantly decreased in MetS compared to controls. 8 % of controls and 30% of MetS North American adult subjects were deficient in 25(OH)D (<20 ng/ml; p=0.0236, Controls vs. MetS). There were no significant differences between the groups with respect to blood sampling in winter and summer months, total calcium and phosphate, and creatinine levels. Vitamin D levels were significantly inversely correlated with fasting glucose (r=−0.29, p=0.04) and HOMA (r=−0.34, p=0.04). Future studies of vitamin D supplementation in these subjects on subsequent risk of diabetes will prove instructive with respect to potential health claims in these high risk patients with MetS.

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Correspondence

I. JialalMD, PhD

Director

Laboratory for Atherosclerosis

and Metabolic Research

UC Davis Medical Center

4635, Second Ave

95817 Sacramento CA

USA

Phone: +1/916/7346 592

Fax: +1/916/7346 593

Email: ishwarlal.jialal@ucdmc.ucdavis.edu