MDR1-Defekt – die 10 häufigsten Fragen

• Literatur

• 1 Barbet JL, Snook T, Gay JM, Mealey KL. ABCB1-1 (MDR1-1) genotype is associated with adverse reactions in dogs treated with milbemycin oxime for general demodicosis. The Authors. Journal compilation ESVD and ACD 2008; 20: 111-114
• 2 Fassler PE, Tranquilli WJ, Paul AJ, Soll MD, Dipietro JA, Todd KS. Evaluation of the safety of ivermectin administered in a beef-based formulation to ivermectin-sensitive Collies. J Am Vet Med Assoc 1991; 199: 457-460
• 3 Geyer J, Klintzsch S, Meerkamp K et al Detection of the nt 230 (del 4) MDR1 mutation in White Swiss Sheperd dogs: case reports of doramectin toxicosis, breed disposition and microsatellite analysis. J Vet Pharm Ther 2007; 30: 482-485
• 4 Hopper K, Aldrich J, Haskins SC. Ivermectin toxicity in 17 Collies. J Vet Int Med 2002; 16: 89-94
• 5 Mealey KL, Gay JM, Martin LG, Waiting DK. Comparison of the hypothalamic-pituitary-adrenal axis in MDR1-1 D and MDR1 wildtype dogs. J Vet Emergency Crit Care 2007; 17: 61-66
• 6 Mealey KL, Bentjen SA, Gay JM, Cantor GH. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 2001; 11: 727-733
• 7 Mealey KL, Bentjen SA, Waiting DK. Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of Collies from the northwestern United States. Am J Vet Res 2002; 63: 479-481
• 8 Mealey KL, Northrup NC, Bentjen SA. Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity. J Am Vet Med Assoc 2003; 223: 1453-1455, 1434
• 9 Meyer D. Therapie der caninen generalisierten Demodikose mit einem Moxidectin-Imidacloprid-Spot-on (Advocate®, Bayer). [Inaug.-Dissertation]. München: 2008
• 10 Mueller RS, Hastie K, Bettenay SV. Daily oral ivermectin for treatment of generalised demodicosis in 23 dogs. Aust Vet Pract 1999; 29: 132-137
• 11 Mueller RS, Bettenay SV. A proposed new therapeutic protocol for the treatment of canine mange with ivermectin. J AAHA 1999; 35: 77-80
• 12 Nelson OL, Carsten E, Bentjen SA, Mealey KL. Ivermectin toxicity in an Australian shepherd dog with the MDR1 mutation associated with ivermectin sensitivity in collies. J Vet Int Med 2003; 17: 354-356
• 13 Paul AJ, Tranquilli WJ, Seward RL, Todd KS, Dipietro JA. Clinical observations in Collies given ivermectin orally. Am J Vet Res 1987; 48: 684-685
• 14 Paul AJ, Tranquilli WJ, Hutchens DE. Safety of moxidectin in avermectin-sensitive collies. Am J Vet Res 2000; 61: 482-483
• 15 Petzinger EB, Döring J, Geyer J, Godoy U, Schirk D. Zahner. Arzneistofftransporter. Spiegel der Forschung 2005; 22: 26-33
• 16 Sartor LL, Bentjen SA, Trepanier L, Mealey KL. Loperamide toxicity in a collie with the MDR1 mutation associated with ivermectin sensitivity. J Vet Int Med 2004; 18: 117-118
• 17 Shoop WL, Mrozik H, Fisher MH. Structure and activity of avermectins and milbemycins in animal health. Veterinary Parasitology 1995; 59: 139-156
• 18 Tranquilli WJ, Paul AJ, Todd KS. Assessment of toxicosis induced by high-dose administration of milbemycin oxime in Collies. Am J Vet Res 1991; 52: 1170-1177