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Planta Med 2011; 77(13): 1542-1544
DOI: 10.1055/s-0030-1270782
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Chemical Constituents, Antimicrobial and Antimalarial Activities of Zanthoxylum monophyllum

Raquel Rodríguez-Guzmán1 , Laura C. Johansmann Fulks1 , Mohamed M. Radwan1 , 2 , Charles L. Burandt1 , Samir A. Ross1 , 3
  • 1National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA
  • 2Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt
  • 3Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS, USA
Further Information

Publication History

received November 18, 2010 revised January 14, 2011

accepted January 19, 2011

Publication Date:
21 February 2011 (online)

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Abstract

From the leaves and bark of Zanthoxylum monophyllum, a new lignan, 3-methoxy-3′,4′-methylenedioxylignan-4,8,9,9′-tetraol (1), has been isolated along with 22 known compounds (2–23), fifteen of them reported for the first time from Z. monophyllum. Their chemical structures were elucidated using detailed spectroscopic studies and chemical analysis. All compounds were evaluated for antimicrobial and antiprotozoal activities. Alkaloids bis-[6-(5,6-dihydro-chelerythrinyl)] ether (2) and 6-ethoxy-chelerythrine (4) exhibited strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA). Compound 4-methoxy-N-methyl-2-quinolone (9) exhibited significant activity against MRSA (IC50 value of 8.0 µM) while compound 5,8,4′-trihydroxy-3,7,3′-trimethoxyflavone (10) showed weak activity against Plasmodium falciparum.

Key words

Zanthoxylum monophyllum - Rutaceae - lignans - alkaloids - antimicrobial - antimalarial activities

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Prof. Dr. Samir A. Ross

National Center for Natural Products Research and Department of Pharmacognosy
School of Pharmacy, The University of Mississippi

University, MS 38677

USA

Phone: +1 66 29 15 10 31

Fax: +1 66 29 15 79 89

Email: sross@olemiss.edu

    www.thieme-connect.de/ejournals/toc/plantamedica