Planta Med 2011; 77(13): 1536-1541
DOI: 10.1055/s-0030-1270797
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Neoclerodane Diterpenoids from Scutellaria barbata

Feng Zhu1 , 2 , Ying-Tong Di1 , Xing-Yao Li1 , Ling-Li Liu1 , Qiang Zhang1 , Yan Li1 , Xiao-Jiang Hao1 , Hong-Ping He1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, P. R. China
  • 2Graduate School of the Chinese Academy of Sciences, Beijing, P. R. China
Further Information

Publication History

received Sept. 14, 2010 revised Nov. 10, 2010

accepted January 24, 2011

Publication Date:
25 February 2011 (online)

Abstract

Eight new neoclerodane diterpenoids (18), scutebatas H–O, together with eight known compounds, have been isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro cytotoxicity of selected compounds against cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480 was evaluated. Compounds 5, 6, 7 showed moderate cytotoxicities against several human cancer cell lines, with IC50 values ranging from 12.6–31.4 µM. In addition, compound 1 showed selective cytotoxicity against MCF-7.

Supporting information available online at http://www.thieme-connect.de/ejournals/toc/plantamedica

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Prof. Dr. Xiao-Jiang Hao

State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences

132 Lanhei Road

Heilongtan

Kunming 650204, Yunnan

P. R. China

Phone: +86 87 15 22 32 63

Fax: +86 87 15 22 30 70

Email: haoxj@mail.kib.ac.cn

Dr. Hong-Ping He

State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences

132 Lanhei Road

Heilongtan

Kunming 650204, Yunnan

P. R. China

Phone: +86 87 15 22 32 63

Fax: +86 87 15 22 30 70

Email: hehongping@mail.kib.ac.cn