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DOI: 10.1055/s-0030-1270935
© Georg Thieme Verlag KG Stuttgart · New York
Four New Carvotanacetone Derivatives from Sphaeranthus ukambensis, Inhibitors of the Ubiquitin-Proteasome Pathway
Publication History
received October 1, 2010
revised February 22, 2011
accepted March 1, 2011
Publication Date:
21 March 2011 (online)

Abstract
Six carvotanacetone derivatives (1–6), amongst which four new compounds (1–4), were isolated from the aerial parts of Sphaeranthus ukambensis Vatke & O. Hoffm. The structures of the molecules were elucidated by complementary spectroscopic methods, and their biological properties were investigated using human DLD-1 colon cancer cells engineered to stably express a 4 ubiquitin-luciferase (4 Ub-Luc) reporter protein. Five of the isolated carvotanacetone derivatives (2–6) were found to inhibit the proliferation of the colon cancer cells and interfere with the ubiquitin-proteasome pathway, with potencies in a micromolar range.
Supporting information available online at http://www.thieme-connect.de/ejournals/toc/plantamedica
Key words
carvotanacetone - Sphaeranthus ukambensis - Compositae - ubiquitin‐proteasome pathway - cancer
- Supporting Information for this article is available online at
- Supporting Information .
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Dr. Isabelle Pouny
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