Planta Med 2011; 77(14): 1569-1574
DOI: 10.1055/s-0030-1270956
Biological and Pharmacological Activity
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

The 2′,4′,6′-Trihydroxyacetophenone Isolated from Myrcia multiflora Has Antiobesity and Mixed Hypolipidemic Effects with the Reduction of Lipid Intestinal Absorption

Eduardo Antonio Ferreira1 , Eliana Fortes Gris1 , Jussara Matos Rebello1 , João Francisco Gomes Correia1 , Luis Flávio Souza de Oliveira1 , Danilo Wilhelm Filho2 , Rozangela Curi Pedrosa1
  • 1Department of Biochemistry, CCB, Federal University of Santa Catarina, Florianópolis, SC, Brazil
  • 2Department of Ecology and Zoology, CCB, Federal University of Santa Catarina, Florianópolis, SC, Brazil
Further Information

Publication History

received July 8, 2010 revised February 10, 2011

accepted March 9, 2011

Publication Date:
06 April 2011 (online)

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Abstract

This study evaluated the hypolipidemic and antiobesity effects of phloroacetophenone (2′,4′,6′-trihydroxyacetophenone, THA) isolated from Myrcia multiflora and their relationship with triglyceride (TG) intestinal absorption and pancreatic lipase activity inhibition. The hypolipidemic effect of THA was evaluated by acute (Triton WR-1339 treatment) and chronic assay (high-fat diet treatment), the antiobesity effect was evaluated by chronic assay (high-fat diet treatment), while the inhibition of enzymatic activity of pancreatic lipase was measured in the intestinal tissue of mice treated with high olive oil concentration. In the acute assay, THA caused greater total cholesterol (37 %) and triglyceride (46 %) serum level reduction than lovastatin (32 and 1 %), a HMG‐CoA reductase inhibitor or orlistat (26 and 34 %), a gastrointestinal lipase inhibitor. In addition, in the chronic assay with a high-fat diet, THA reduced cholesterol and triglyceride levels (32 and 61 %, respectively) while lovastatin showed a decrease of 35 and 49 %, respectively. THA also caused a reduction in weight gain very similar to orlistat (40 and 38 %, respectively) when the animals were submitted to a high-fat diet. Moreover, THA showed a stronger and continuous pancreatic lipase inhibitory activity when compared with orlistat, causing inhibition of this enzyme during 6 hours associated to a significant reduction of triglyceride serum levels. The in vivo antiobesity and hypolipidemic effects of THA may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.